Creatine in Osteoarthritis

Creatine supplementation improves physical function, lower limb lean mass and quality of life

Amplify’d from
Med Sci Sports Exerc. 2011 Feb 8. [Epub ahead of print]

Beneficial Effect of Creatine Supplementation in Knee Osteoarthritis.


1 School of Medicine, Division of Rheumatology – University of Sáo Paulo; 2 School of Physical Education and Sport, Department of Byodinamics – University of Sáo Paulo.



The aim of this study was to investigate the efficacy of creatine (CR) supplementation combined with strengthening exercises inknee osteoarthritis (OA).


A randomized, double-blind,placebo-controlled trial was performed.Postmenopausal women with knee OA were allocated to receive either CR (20 g/dfor one week and 5 g/dthereafter) or placebo (PL) and were enrolled in a lower limb resistance training program. They were assessed at baseline (PRE) and after 12 weeks (POST). The primary outcome was the physical function as measured by the timed-stands test. Secondary outcomes included lean mass, quality of life, pain, stiffness, and muscle strength.


Physical function was significantly improved only in the CR group (p=0.006). Additionally, a significant between-group difference was observed (CR-PRE: 15.7 ± 1.4, POST: 18.1 ± 1.8; PL-PRE: 15.0 ± 1.8, POST: 15.2 ± 1.2; p=0.004). The CR group also presented improvements in physical function and stiffness subscales as evaluated by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) (p=0.005 and p=0.024, respectively), whereas the PL group did not show any significant changes in these parameters (p>0.05). Additionally, only the CR group presented a significant improvement in lower limb lean mass (p=0.04) as well as in quality of life (p=0.01). Both CR and PL groups demonstrated significant reductions in pain (p<0.05). Similarly, a main effect for time revealed an increase in leg-press 1-RM (p=0.005) with no significant differences between groups (p=0.81).


CR supplementation improves physical function, lower limb lean mass and quality of life in postmenopausal women with knee OA undergoing strengthening exercises. number: NCT00992043.



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