There is Good Poop and Bad Poop

Watch the bacteria in your gut.
Eat a healthy diet full of lactobacteria (yogurt)
You do not want a Stool transplant!

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Stool Transplants Stop 90% of C difficile Recurrences

Sandra Yin

November 1, 2011 (National Harbor, Maryland/Washington, DC) — Multiple courses of standard antibiotic treatment often fail in patients with recurrent Clostridium difficile infections (CDIs), with recurrence rates reaching 50%. But a study presented here at the American College of Gastroenterology (ACG) 2011 Annual Scientific Meeting and Postgraduate Course pointed to a highly successful alternative.

Fecal microbiota transplants (FMTs), also known as stool transplants, succeeded in 91% of patients with recurrent CDI who had undergone 2 or more failed courses of treatment, including alternative antibiotics, pulse and tapered vancomycin, and probiotics, according to Mark Mellow, MD, director of the Digestive Health Center at INTEGRIS Baptist Medical Center in Oklahoma City, who was the study’s lead author.

“I think we have clearly shown that [FMT] is an effective treatment for patients who have had 2 or more previous episodes of C difficile infection, that it seems to be quite safe in the short term and in the relatively long term, and it’s really long lasting,” Dr. Mark Mellow told Medscape Medical News.

No patient developed recurrent CDI after the transplant without subsequently taking antibiotics. The transplants were not as successful in people who had to take antibiotics for some other infection.

Despite having CDI for an average of 11 months on average, the patients responded to the stool transplant in just 6 days. None of the patients developed recurrent CDI without subsequently taking antibiotics during follow-up. During the long-term follow-up, 30 patients took antibiotics for other infections; CDI recurred in 8 (27%) of those patients but none of the other patients.

In other findings, the average durations to resolution and improvement in diarrhea and fatigue were 6 days and 4 weeks, respectively.

The study involved 77 mostly elderly, debilitated patients who had a colonoscopic FMT for recurrent CDI. Patients completed a 36-item survey via mail or by phone at least 3 months after their fecal transplant. Treatment failure was defined as continued CDI or recurrence within 3 months of FMT. The average follow-up time after FMT was 17 months.

Patients who underwent colonoscopic FMT found it so effective that more than half (53%) said that a fecal microbiota transplant would be their top choice if they contracted CDI again.

Dr. Mellow called on physicians and lay people to think of stool as more than “just a smelly inert substance.” It is also a biologically active substance that secretes material capable of killing pathogens, he said.



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