Plavix Increases Post Op Bleeding!

Plavix, clopidogrel use within 7 days of an operation significantly increased the risk of postoperative bleeding! Plavix, clopidogrel cessation 7 days before operation is recommendedAmplify’d from http://www.ncbi.nlm.nih.govArch Surg. 2011 Mar;146(3):334-9.Cessation of clopidogrel before major abdominal procedures.Chernoguz A, Telem DA, Chu E, Ozao-Choy J, Tammaro Y, Divino CM.Department of Surgery, Mount Sinai School of Medicine, 5 … Continue reading Plavix Increases Post Op Bleeding!

Proton Pump Inhibitors May Reduce the Efficacy of Clopidogrel

Proton Pump Inhibitors May Reduce the Efficacy of Clopidogrel Proton Pump Inhibitor Effect to Reduce Clopidogrel Conversion to Its Active Metabolite Proton Pump Inhibitor Interaction with Clopidogrel (Plavix®) Omeprazole (Prilosec®, Zegerid®) Confirmed Gilard1, Juurlink2, Ho3 Rabeprazole (Aciphex®) Probable Juurlink2, Ho3 Lansoprazole (Prevacid®) Questionable Gilard1, Juurlink2, Li5 Esomeprazole (Nexium®) Unlikely Siller-Matula4 Pantoprazole (Protonix®) Unlikely Juurlink2, Siller-Matula4Amplify’d … Continue reading Proton Pump Inhibitors May Reduce the Efficacy of Clopidogrel

drug interaction clopidogrel/plavix and omeprazole/prilosec not clopidogrel and pantoprazole/protonix

drug interaction clopidogrel/plavix and omeprazole/prilosec not clopidogrel and pantoprazole/protonix The results suggest that a metabolic drug–drug interaction exists between clopidogrel and omeprazole but not between clopidogrel and pantoprazole. Omeprazole (Brand names: Losec, Omesec, Prilosec, UlcerGard, Zegerid) Pantoprazole (Brand name: Protonix)Amplify’d from http://www.nature.comClinical Pharmacology & Therapeutics (2010); advance online publication 15 September 2010. doi:10.1038/clpt.2010.219Differential Effects of … Continue reading drug interaction clopidogrel/plavix and omeprazole/prilosec not clopidogrel and pantoprazole/protonix