Statistical Significance and Clinical Relevance The Importance of Power in Clinical Trials

Statistical Significance and Clinical RelevanceThe Importance of Power in Clinical Trials in DermatologySachin S. Bhardwaj, MD; Fabian Camacho, MS; Amy Derrow, MS;Alan B. Fleischer, Jr, MD; Steven R. Feldman, MD, PhDWhen evaluating the validity of a study, the reader must consider both the clinicaland statistical significance of the findings. A study that claims clinical relevancemay …

The Meanings and Measurement of Clinical Significance

The Meanings and Measurement of Clinical SignificanceAlan E. Kazdin Yale UniversityThe previous articles in this special section make the case for the importance of evaluating the clinical significance of therapeutic change, present key measures and innovative ways in which they are applied, and more generally provide important guidelines for evaluating therapeutic change. Fundamental issues raised …

Statistical significance — a misconstrued notion in medical research

Statistical significance -- a misconstrued notion in medicalresearch1Nurminen M.2Scandinavian Journal of Work Environment and Health 1997;23(3):232-5.Abstract The P-value is the significance probability of obtaining a value of the test statistic that isas extreme, in relation to the null hypothesis, as that observed. Medical researchers may, in somesituations, disagree on its appropriate use or on its …

Statistical Significance Versus Clinical Importance

Statistical significance tells us that an observed difference is reliable, but whether the difference is large enough to be important cannot be resolved by applying a statistical formula. The more important recent issue seems to be a study published in The Lancet which indicates a 9% increased risk of Type 2 diabetes associated with Crestor. As …

The 25 Worst Mistakes In History, Captain Edward Smith crashes the Titanic into an iceberg

The 25 Worst Mistakes In History, Captain Edward Smith crashes the Titanic into an icebergMoney lost in 1909: $7.5 million in shipbuilding costsInflation-adjusted: $168 million The passenger liner, The Titanic, sunk on its maiden voyage from England to the United States in 1912. The Titanic was known as the unsinkable ship, specifically designed to make the long journey to America …

The 25 Worst Mistakes In History, Faulty equipment causes the Challenger to explode on liftoff

The 25 Worst Mistakes In History,  Faulty equipment causes the Challenger to explode on liftoffWikipediaMoney lost in 1986: $5.5 billion was the cost of building the ChallengerInflation adjusted value: $11.1 billionIn January of 1986, the Challenger, a NASA space shuttle, exploded just 72 seconds into its flight. All seven crew members on board died in the explosion.The explosion was blamed …

Worst Mistakes In History, Mercedez-Benz buys Chrysler

Worst Mistakes In History, Mercedez-Benz buys ChryslerOverpayment in 1998: $20 billionInflation-adjusted:  $26.6 billionIn 1998, Mercedes-Benz merged with Chrysler to create Daimler Chrysler, for $37 billion. But the merger didn't work out as planned and by 2007, Mercedes sold Chrysler Cerberus Capital Management for only $7 billion.Read more: http://www.businessinsider.com/worst-mistakes-in-history-2011-4#mercedez-benz-buys-chrysler-22#ixzz1sWrhCCpW

Worst Mistakes In History Faulty equipment causes nuclear meltdown at Chernobyl

Worst Mistakes In HistoryFaulty equipment causes nuclear meltdown at Chernobylwikipedia commonsMoney lost in 1986: $358 billion in clean-up and the value of lost farmlandInflation adjusted price: $720 billionIn 1986, four reactors went out of control during a test which led to an explosion and fire. The fire destroyed the reactor building in its entirety. The explosion also released an unsafe …

Remaining silent in the face of injustice is the same as supporting it.

Remaining silent in the face of injustice is the same as supporting it.

Very Low Calorie Diet => 20% Decrease in BMI similar to Lap Band

   Overall severely obese subjects had an major weight loss after6-month very low calorie diet.Patients lost an average of 25 + 10 kg after the 6-month very low calorie diet,= -20% of their original body weight.The Mean BMI decreased from 45 + 5 kg/m2 to38 + 5 kg/m2 P < 0.001,= -19% of decrease from their original BMI.Mean waist circumference decreased from …